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Among all the neurologic diseases of adult life, the cerebrovascular ones clearly rank rst in frequency and importance At least 50 percent of the neurologic disorders in a general hospital are of this type At some time or other, every physician will be required to examine patients with cerebrovascular disease and should at least know something of the common types particularly those in which there is a reasonable prospect of successful medical or surgical intervention or the prevention of recurrence There is another advantage to be gained from the study of this group of diseases namely, that they have traditionally provided one of the most instructive approaches to neurology As our colleague C M Fisher has aptly remarked, house of cers and students learn neurology literally stroke by stroke Moreover, the focal ischemic lesion has divulged some of our most important ideas about the function of the human brain It must also be noted that, in the last two decades, new and extraordinary types of imaging technology have been introduced that allow the physician to make physiologic distinctions between normal, ischemic, and infarcted brain tissue This biopathologic approach to stroke will likely guide the next generation of treatments and has already had a pronounced impact on the direction of research in the eld Salvageable brain tissue to be protected in the acute phase of stroke can be delineated by these methods To identify this ischemic but not yet infarcted tissue virtually de nes the goal of modern stroke treatment Which of the sophisticated imaging techniques will contribute to improved clinical outcome is still to be determined, but certain ones, such as diffusionweighted imaging, have already proved invaluable in stroke work Despite these valuable advances in stroke neurology, three points should be made First, all physicians have a role to play in the prevention of stroke by encouraging the reduction in risk factors such as hypertension and the identi cation of signs of potential stroke, such as transient ischemic attacks, atrial brillation, and carotid artery stenosis Second, careful bedside clinical evaluation integrated with the newer testing methods mentioned above still provide the most promising approach to this category of disease Finally, the last decade or two have witnessed a departure from the methodical clinicopathologic studies that have been the foundation of our understanding of cerebrovascular disease Increasingly, randomized studies involving several hundred and even thousands of patients and conducted simultaneously in dozens of institutions have come to dominate investigative activity in this eld These multicenter trials have yielded highly valuable information about the natural history of a variety of cerebrovascular disorders, both symptomatic and asymptomatic However, this approach suffers from a number of inherent weaknesses, the most important of which is that the homogenized data derived from an aggregate of patients may not be applicable to a speci c case at hand Moreover, many large studies show only marginal differences between treated and control groups Each of these multicenter studies will therefore be critically appraised at appropriate points in the ensuing discussion. how to open pdf file in new window in asp.net c# E5095 - How to implement a simple PDF viewer in web ASP.NET ...
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hi all, i want to open pdf file in new window. it opens the pdf file in ... http:// stackoverflow.com/questions/11100981/asp-net- mvc - open - pdf -file-in- ... country approximately 700,000 cases of stroke roughly 600,000 ischemic lesions and 100,000 hemorrhages, intracerebral or subarachnoid with 175,000 fatalities from these causes Since 1950, coincident with the introduction of effective treatment for hypertension, there has been a substantial reduction in the frequency of stroke This was most apparent three decades ago, as treatment for high blood pressure became a public health focus Among the residents of Rochester, Minnesota, Broderick and colleagues documented a reduction of 46 percent in cerebral infarction and hemorrhage when the period 1975 1979 was compared with 1950 1954; Nicholls and Johansen reported a 20 percent decline in the United States between 1968 and 1976 Both sexes shared in the reduced incidence During this period, the incidence of coronary artery disease and malignant hypertension also fell signi cantly By contrast, there has been no change in the frequency of aneurysmal rupture Interestingly, despite the continued improvement in the treatment of hypertension, the incidence rate of stroke for the period 1980 1984 was 17 percent higher than that for 1975 1979, a feature attributed by Broderick and coworkers to the widespread use of computed tomography (CT), which increased the detection of less severe strokes In the last decade, according to the American Heart Association, the mortality rate from stroke has declined by 12 percent, but the total number of strokes may again be rising asp net mvc 5 pdf viewer How To Open PDF File In New Tab In MVC Using C# - C# Corner
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